新品发布:氢氘交换质谱(HDX-MS)技术服务

了解详情

基因功能研究专项

基因、表型、互作,带你玩转植物生物学研究套路。

抗原抗体定制

成熟的重组蛋白表达 平台、先进的抗体研发中心为高质量的抗原抗体交付提供保障。

快速检测试剂开发

胶体金试纸条定制ELISA试剂盒研发化学发光试剂研发,合作开发及技术转让等多种合作模式。

科研服务伙伴

为基础科研提供一站式基因、蛋白、抗体解决方案和全面的科研技术服务。

知识分享

实验操作分享,钟鼎10余年科研经验总结。

特色服务&产品

闻道有先后,术业有专攻,钟鼎特色服务位居业界前列

Southern Blot印记杂交检测服务

传统的胶片曝光与更前沿的自动化学发光成像检测系统相结合,确保捕获更好信噪比的成像时间点。

DAP-seq技术服务

成功将体内结合实验转移到体外,解决了ChIP抗体制备的困扰,极大的提高 DNA Binding Site发现的效率。

微量热泳动(MST)技术服务

待检测的互作生物分子可以是蛋白-抗体,蛋白-蛋白,蛋白-DNA/RNA蛋白-小分子化合物等。

小分子pull down

研究小分子化合物结合的靶蛋白,进而确认与靶蛋白的结合位点。用于小分子靶点发现、创新药物先导化合物筛选等。

协助用户发表文献

蛋白表达

*Natural variations in the promoter of ZmDeSI2 encoding a deSUMOylating isopeptidase controls kernel methionine content in maize.10.1016/j.molp.2025.04.008(IF=17.1)
*SARS-CoV-2 envelope protein impairs airway epithelial barrier function and exacerbates airway inflammation via increased intracellular Cl− concentration.Signal Transduction and Targeted Therapy (2024) 9:74(IF=40.8)
*Malaria oocysts require circumsporozoite protein to evade mosquito immunity.NATURE COMMUNICATIONS | (2022) 13:3208(IF=14.7)
*Identification and functional characterization of a novel BEL1-LIKE homeobox transcription factor GmBLH4 in soybean.https://doi.org/10.1007/s11240-018-1419-4(IF=12.085)
*Nanopore efficiently identifies hepatitis D virus antigens in vitro assay.Materials Today Physics 46 (2024) 101479(IF=10)
*Lactate modulates iron metabolism by binding soluble adenylyl cyclase., Cell Metabolism.(IF=27.7)
*Adenosine Monophosphate-Activated Protein Kinase (AMPK) Phosphorylation Is Required for 20-Hydroxyecdysone Regulates Ecdysis in Apolygus lucorum.Published: 11 May 2023.doi:10.3390/ijms24108587(IF=5.6)
*Integration of genome wide association studies and coexpression networks reveal roles of PtoWRKY 42-PtoUGT76C1-1 in trans-zeatin metabolism and cytokinin sensitivity in poplar.New Phytologist (2021) 231: 1462–1477doi: 10.1111/nph.1746(IF=9.4)
*Targeting HLA-F suppresses the proliferation of glioma cells via a reduction in hexokinase 2-dependent glycolysis.International Journal of Biological Sciences.Published: 2021.03.25.doi:10.7150/ijbs.56357(IF=9.2)
*Discovery of Clinical Candidate (5-(3-(4-Chlorophenoxy)prop-1-yn-1-yl)-3-hydroxypicolinoyl)glycine, an Orally Bioavailable Prolyl Hydroxylase Inhibitor for the Treatment of Anemia.2020, 63, 17, 10045–10060(IF=7.3)
* Identification and validation of reference genes for quantitative real-time PCR studies in long yellow daylily, Hemerocallis citrina Borani. Feifan hou.PLoS One. 2017, doi: 10.1371/journal.pone.0174933
* Transcriptional profiling analysis of Spodoptera litura larvae challenged with Vip3Aa toxin and possible involvement of trypsin in the toxin activation.Feifei Song et.al.Sci Rep. 2016; 6: 23861.doi: 10.1038/srep23861
* Activation of PPARγ by a Natural Flavonoid Modulator, Apigenin Ameliorates Obesity-Related Inflammation Via Regulation of Macrophage Polarization.et al.Xiujing Feng et al.EBioMedicine. 2016 Jul; 9: 61–76.doi:10.1016/j.ebiom.2016.06.017
* Molecular characterisation of the vitellogenin gene (AlVg) and its expression after Apolygus lucorum had fed on different hosts. Sun Y et al. Pest Management Science, Volume 72, Issue 9, 22 JAN 2016.
* Hydrogen Sulfide Regulates Krüppel‐Like Factor 5 Transcription Activity via Specificity Protein 1 S‐Sulfhydration at Cys664 to Prevent Myocardial Hypertrophy.Guoliang Meng et al. J Am Heart Assoc. 2016 Sep; 5(9): e004160.doi: 10.1161/JAHA.116.004160

分子生物学

*Acetylated mitochondrial MDH2 regulates CTR2 transcription to induce cuproptosis during Escherichia coli infection.Nature Communications(2026).(IF=15.7
*Magnaporthe oryzae MoPh1 perceives ER stress and promotes adaptive responses via a plasma membrane-to-vacuole pathway.Nature Communications(2026).(IF=15.7
*Targeting SCAMP2 by a natural product auxarconjugatin B for glioblastoma therapy via restoring aspartate metabolic flux.10.1016/j.apsb.2026.02.018 .(IF=11.6
*UBTF–HSP90A–MIF stress circuit drives lenvatinib resistance and immune exclusion in hepatocellular carcinoma.Journal of Advanced Research(2026).(IF=11.4
*4,5-Dichloro-2-n-octyl-4-isothiazolin-3-one induces obesogenic effects by targeting fatty acid synthase.Journal of Hazardous Materials 511 (2026) 142299.(IF=14.6
*Natural variations in the promoter of ZmDeSI2 encoding a deSUMOylating isopeptidase controls kernel methionine content in maize.Molecular Plant 18, 872–891, May 5 2025.DOI:10.1016/j.molp.2025.04.008(IF=24)
*Targeting GRP75 with a Chlorpromazine Derivative Inhibits Endometrial Cancer Progression Through GRP75–IP3R-Ca2+-AMPK Axis.Adv. Sci. 2024, 11, 2304203(IF=14.3)
*Hypericin photoactivation induces triple-negative breast cancer cells pyroptosis by targeting the ROS/CALR/Caspase-3/GSDME pathway. (IF=11.3
*The ZmbHLH32-ZmIAA9-ZmARF1 module regulates salt tolerance in maize.International Journal of Biological Macromolecules 253 (2023) 126978(IF =8.4)
*Biallelic intronic AAGGG expansion of RFC1 is related to multiple system atrophy.Annals of Neurology(2020)(IF =9.037)
*Regulatory mechanism of MeGI on sexuality in Diospyros oleifera.Front. Plant Sci., 22 February 2023(IF =6.627)
*High Osmotic Stress Increases OmpK36 Expression through the Regulation of KbvR to Decrease the Antimicrobial Resistance of Klebsiella pneumoniae.spectrum on 06 June 2022 by 113.56.232.76(IF=9.04)
*A sugarcane smut fungus effector simulates the host endogenous elicitor peptide to suppress plant immunity.New Phytologist (2021)doi:10.1111/nph.17835(IF=9.4)
*The minicircular and extremely heteroplasmic mitogenome of the holoparasitic plant Rhopalocnemis phalloides.Published:December 13, 2021(IF= 9.49)
*WRKY46 promotes ammonium tolerance in Arabidopsis by repressing NUDX9 and IAAconjugating genes and by inhibiting NH4+efflux in the root elongation zone.(2021) DOI: 10.1038/s41438-020-0327-z(IF=8.55)
*CsMYB60 directly and indirectly activates structural genes to promote the biosynthesis of flavonols and proanthocyanidins in cucumber Hortic Res. doi: 10.1038/s41438-020-0327-z.(IF=5.4)
*A WD40-Repeat Protein From the Recretohalophyte Limonium bicolor Enhances Trichome Formation and Salt Tolerance in Arabidopsis. 2019 Nov 12.(IF=5.6)
*Genetically modified pigs are protected from classical swine fever virus.PLOS Pathogens, 2018; 14 (12): e1007193 DOI: 10.1371/journal.ppat.1007193(IF=6.7)

 

免疫学

*Editing strigolactone hormone receptor for robust antiviral silencing in rice.Cell 189, 1–19, April 2, 2026(IF=42.5)
*Phosphorylation by mTORC1 stablizes Skp2 and regulates its oncogenic function in gastric cancer.Molecular Cancer (2017) 16:83(IF=27.69)
*Crystal structure and cellular functions of uPAR dimer.Nature Communications.Published: 29 March 2022.(IF=16.6)
*Inhibiting bridge integrator 2 phosphorylation leads to improved oocyte quality, ovarian health and fertility in aging and after chemotherapy in mice.Nature Aging(IF=16.6)
*PKCβII phosphorylates ACSL4 to amplify lipid peroxidation to induce ferroptosis.Nature Cell Biology,2022(IF=17.728)
*Malaria oocysts require circumsporozoite protein to evade mosquito immunity.NATURE COMMUNICATIONS | (2022) 13:3208(IF=14.7)
*Transglutaminase 2 crosslinks zona pellucida glycoprotein 3 to prevent polyspermy.Cell Death & Differentiation (2022) 29:1466–1473(IF=13.7)
*NLRP4E regulates actin cap formation through SRC and CDC42 during oocyte meiosis.Cellular & Molecular Biology Letters(2024) 29:68(IF=9.2)
*The engineered CRISPR-Mb2Cas12a variant enables sensitive and fast nucleic acid-based pathogens diagnostics in the field.First published: 17 April 2023 DOI:10.1111/pbi.14051(IF=13.8 )
*The DnaJ domain-containing heat-shock protein NAL11 determines plant architecture by mediating gibberellin homeostasis in rice (Oryza sativa).23 December 2022 DOI:10.1111/nph.18696(IF=10.323 )

 

行业资讯

聚焦生命科学最新前沿

MORE

钟鼎速览

高新技术企业 5000平米自建实验室 创新专利墙 博士领衔技术团队